The metabolism of acetamidothiazoles in the rat. 2-Acetamido-, 2-acetamido-4-methyl- and 2-acetamido-4-phenyl-thiazole
نویسندگان
چکیده
منابع مشابه
Methyl 2-acetamido-2-(4-hydroxy-2-methyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-4-yl)-4-methylpentanoate
In the isoquinoline ring system of the title mol-ecule, C(19)H(24)N(2)O(6), the N-heterocyclic ring is in a half-boat conformation. The mol-ecular structure is stabilized by an intra-molecular O-H⋯O hydrogen bond, which generates an S(7) ring motif. In the crystal, mol-ecules are linked via inter-molecular bifurcated N-H⋯(O,O) and weak C-H⋯O hydrogen bonds into a three-dimensional network.
متن کامل2-Methoxyphenyl 2-{2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetamido}acetate
The title compound, amtolmetin guacil, C(24)H(24)N(2)O(5), is a new gastroprotective non-steroidal anti-inflammatory drug. In the crystal structure, the drug mol-ecule is linked into a one-dimensional structure along the c axis by weak N-H⋯O inter-actions between the amide groups. C-H⋯O and C-H⋯π inter-actions influence the packing.
متن کاملCrystal structure of methyl 5-acetamido-2-t-butyl-2-methyl-1,3-benzodioxole-4-carboxylate.
1,3-benzodioxle-4-carboxylic acid] was designed as a novel class of chiral fluorometric agents.1 The chiral agent and the analogues have been conveniently applied to enantiomer analyses of various bio-molecules using HPLC and circular dichroism.2 We recently extended the molecular design of (S)TBMB carboxylic acid to chiral nitrobenzoic acids possessing the asymmetric 1,3-benzodioxole.3 The chi...
متن کامل2-[N-(4-Methoxyphenyl)acetamido]-1,3-thiazol-4-yl acetate
The structural analysis of the title compound, C14H14N2O4S, particularly the presence of an acetyl group at the exocyclic N atom and the C(H)-C(O2CMe)-N acet-oxy group in the thia-zole ring, may indicate that one of the starting materials, i.e. 2-(4-meth-oxy-anilino)-1,3-thia-zol-4(5H)-one, exists in the reaction mixture, at least partially, as a tautomer with an exocyclic amine N atom and an e...
متن کامل2-Acetamido-4-p-tolyl-1,3-thiazole and 2-amino-4-p-tolyl-1,3-thiazolium chloride dihydrate.
The structures of 2-acetamido-4-tolyl-1,3-thiazole, C(12)H(12)N(2)OS, (I), and 2-amino-4-tolyl-1,3-thiazolium chloride dihydrate, C(10)H(11)N(2)S(+).Cl(-).2H(2)O, (II), reveal that both molecules are essentially planar, with the respective dihedral angles between the benzene and thiazole rings being 2.9 (1) and 10.39 (7) degrees . Compound (I) associates via a single N-H...O interaction to form...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1973
ISSN: 0264-6021
DOI: 10.1042/bj1340869